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Current BioPhysics Great Lab Research Projects

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Biophysical mechanism of anesthesia,  Dr. David Busath
We are testing the rogue hypothesis that volatile general anesthetics work indirect by changing either lipid membrane thickness (dissolving rafts) or lateral pressure profile. These changes may change helix bundle tilt for ion channels, e.g. M2, KcsA, MscL, ligand-gated channels, and gap junctions.

For Additional Information please contact: Prof. David Busath
Updated: 5/1/2008 8:56:31 AM

Botulinum as anticonvulsant,  Dr. David Busath
Botulinum toxin may enter the cranial cavity and affect central neurons. We are testing the hypothesis that the toxin could inhibit seizures using rats with electrodes implanted in the hippocampus.

For Additional Information please contact: David Busath and Scott Steffensen
Updated: 5/1/2008 9:00:24 AM

Botulinum chaperoning,  Dr. David Busath
The botulinum toxin heavy chain transports the light chain from the endosome into the cytoplasm. We are exploring what factors control the binding and incorporation of the heavy chain into the membrane, and the conformational conversion involved.

For Additional Information please contact: David Busath
Updated: 5/1/2008 8:58:29 AM

M2 Study,  Dr. David Busath
While focusing our efforts on purifying the membrane fraction from E-coli in profusion electrophysiology experiments we are able to measure the lorentzian component of the channel/membrane noise signal.

For Additional Information please contact: Chris Larson
Updated: 4/7/2008 5:53:49 PM

metaplasticity of CA1 hippocampus,  Dr. Jeff Edwards
Electrophysiological experiments on rat brain slices combined with pharmacology to access the effects of various drugs on metaplasticity of the hippocampus. One form of plasticity, LTP is the mediator or short-term memory formation.

For Additional Information please contact:
Updated: 2/15/2008 12:55:04 PM

Molecular Biology of hippocampal interneurons,  Dr. Jeff Edwards
Combining electrophysiology and RT-PCR we will determine the function of various types of plasticity have on overall hippocampal function using molecular biology to distinguish cell subtypes and cellular components necessary to drive the plasticity.

For Additional Information please contact:
Updated: 2/15/2008 12:57:32 PM

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This page is constantly being updated....if you have information that would be related to current Biophysics Great Lab Research please contact us at pdbio.greatlab@gmail.com